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Definitions

Severe Sepsis

Presence of sepsis with one or more of the following:

• Acute end organ dysfunction, (thrombocytopenia, coagulopathy, altered mental status, respiratory failure, oliguria, acute kidney injury)
• hypotension
• hypoperfusion

Lactate ≥ 4mmol/L

Sepsis Shock

• Presence of sepsis with hemodynamic instability that persists despite aggressive fluid challenge 
• SBP less than 90mmHg or 40mmHg decrease from baseline or MAP less than 65mmHg after 30ml/kg fluid bolus over 30 min

Multiple Organ Dysfunction Syndrome

• Dysfunction of more than one organ - Homeostasis must be maintained with immediate intervention.

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